Molecular Epidemiology for Infectious Diseases: An Introduction to Understanding and Interpreting Molecular Epidemiology
暫譯: 傳染病的分子流行病學：理解與詮釋分子流行病學的入門指南
Field, Nigel, Oeser, Clarissa, Coltart, Cordelia E. M.
- 出版商: Springer
- 出版日期: 2025-09-27
- 售價: $4,860
- 貴賓價: 9.5 折 $4,617
- 語言: 英文
- 頁數: 223
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3031764471
- ISBN-13: 9783031764479
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相關分類:
Data Science
海外代購書籍(需單獨結帳)
商品描述
This textbook introduces the reader to molecular epidemiology as a field that improves our understanding of infectious diseases, their natural history, and their control. The sudden onset of the COVID-19 pandemic prompted an increased awareness about epidemiology and molecular biology. Policy makers have required specialist knowledge to assess the evolving situation and make informed judgements about the clinical and public health implications.
This book bridges the gap between primary research and advanced graduate textbooks.
The field of molecular epidemiology has developed at the interface between epidemiology and molecular biology as high throughput molecular techniques have become cheaper and increasingly sophisticated for typing pathogen strains and characterising the host immune response. At the same time, bioinformatics and statistical methods have evolved so these complex and high-dimensional data can be analysed in combination with classical epidemiological data on time, person, and place. However, the analysis of datasets combining classical epidemiological and molecular data is highly specialised. Few postgraduate courses cover this topic in sufficient detail to allow meaningful interpretation.
This textbook introduces the major methods used to generate molecular datasets and the epidemiological and statistical concepts that are used to link these data with clinical and behavioural data. An introductory chapter explains key terms, definitions and the challenges of accurate and reproducible measurements in microbiology (metrology) and reviews the development of molecular epidemiology as a field and its history. Subsequent chapters introduce the readers to pathogen phylogenetics, host transcriptomics, proteomics, serology, and the microbiome. An additional chapter covers the ethical issues that arise when using molecular data combined with epidemiological and clinical information. The concluding chapter takes a look at the bigger picture and considers the contributions of molecular epidemiology to infectious disease control and health policy.
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商品描述(中文翻譯)
這本教科書介紹了分子流行病學作為一個領域，增進我們對傳染病、其自然歷史及控制方法的理解。COVID-19疫情的突然爆發促使人們對流行病學和分子生物學的認識提高。政策制定者需要專業知識來評估不斷變化的情況，並對臨床和公共衛生的影響做出明智的判斷。
本書填補了基礎研究與高級研究生教科書之間的空白。
分子流行病學的領域在流行病學和分子生物學的交界處發展，隨著高通量分子技術變得更便宜且越來越複雜，用於分型病原體菌株和特徵化宿主免疫反應。同時，生物資訊學和統計方法也在發展，使得這些複雜且高維度的數據可以與傳統流行病學數據（如時間、個體和地點）結合進行分析。然而，結合傳統流行病學和分子數據的數據集分析是高度專業化的。很少有研究生課程能夠詳細涵蓋這一主題，以便進行有意義的解釋。
這本教科書介紹了生成分子數據集的主要方法，以及用於將這些數據與臨床和行為數據聯繫起來的流行病學和統計概念。引言章節解釋了關鍵術語、定義以及在微生物學（計量學）中準確和可重複測量的挑戰，並回顧了分子流行病學作為一個領域的發展及其歷史。隨後的章節將讀者介紹給病原體系譜學、宿主轉錄組學、蛋白質組學、血清學和微生物組。另一章則涵蓋了在使用結合流行病學和臨床信息的分子數據時出現的倫理問題。結尾章節則從更大的視角看待，考慮分子流行病學對傳染病控制和健康政策的貢獻。
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作者簡介
Nigel Field is Professor of Infectious Diseases Epidemiology, Director of the UCL Centre of Molecular Epidemiology and Translational Research at the Institute for Global Health (IGH), Co-Director of the MSc Applied Infectious Diseases Epidemiology AIDE, Author of STROME-ID and of STROBE-Metagenomics on molecular epidemiology. He is an infectious disease epidemiologist specialising in large-scale studies using molecular epidemiology to gain insights about acquisition and transmission of gut microbiota and a range of pathogens.
Clarissa Oeser is an Infectious Diseases Epidemiologist with a background in paediatric infectious diseases and molecular diagnostics. She is co-lead of the Molecular Epidemiology for Infectious Diseases MSc AIDE module at UCL and co-author of STROBE-Metagenomics. Her research interest is in early life exposures and their effect on infectious outcomes in childhood.
Cordelia E. M. Coltart is Consultant Clinical Academic in Infectious Diseases in the Division of Infection and Immunity at UCL and the Royal Free Hosptial NHS trust, dividing her time between clinical work and academia. Her research investigates the utility of pathogen genomics for public health benefit - focussing on integrating pathogen genomics with epidemiology to inform the early detection, management and control of infectious diseases, both at a patient and population level. She developed and co-led the Molecular Epidemiology for Infectious Diseases MSc module at UCL.
Heather Bailey is an Associate Professor in Infectious Disease Epidemiology at the Institute for Global Health, University College London. Her research interests lie in the impact of infections on maternal and child health, including vertical transmission, its consequences, and prevention.
Maryam Shahmanesh is Professor of Global Health at IGH, UCL, Consultant Physician in HIV at the Mortimer Market Centre, and Faculty Lead for clinical research at the Africa Health Research Institute in KwaZulu-Natal, South Africa. She brings expertise in working in the interdisciplinary space between social science, clinical research, and epidemiology. She has developed two interdisciplinary MSc courses at UCL, in Population Health, and in Applied Infectious Disease Epidemiology.
作者簡介(中文翻譯)
Nigel Field 是傳染病流行病學教授，倫敦大學學院（UCL）全球健康研究所分子流行病學與轉化研究中心主任，應用傳染病流行病學碩士課程（MSc Applied Infectious Diseases Epidemiology AIDE）共同主任，並且是《STROME-ID》和《STROBE-Metagenomics》在分子流行病學方面的作者。他是一位專注於大型研究的傳染病流行病學家，利用分子流行病學來深入了解腸道微生物群的獲取和傳播以及各種病原體。
Clarissa Oeser 是一位傳染病流行病學家，擁有兒科傳染病和分子診斷的背景。她是倫敦大學學院（UCL）傳染病分子流行病學碩士課程（MSc AIDE）模組的共同負責人，也是《STROBE-Metagenomics》的共同作者。她的研究興趣在於早期生命暴露及其對兒童傳染病結果的影響。
Cordelia E. M. Coltart 是倫敦大學學院（UCL）感染與免疫學部門的傳染病臨床學術顧問，並在皇家自由醫院（Royal Free Hospital NHS Trust）工作，將時間分配於臨床工作和學術研究之間。她的研究探討病原體基因組學對公共健康的效用，專注於將病原體基因組學與流行病學整合，以促進傳染病的早期檢測、管理和控制，無論是在患者還是整體人群層面。她在UCL開發並共同主導了傳染病分子流行病學碩士模組。
Heather Bailey 是倫敦大學全球健康研究所的傳染病流行病學副教授。她的研究興趣在於感染對母嬰健康的影響，包括垂直傳播、其後果及預防措施。
Maryam Shahmanesh 是倫敦大學學院（UCL）全球健康教授，Mortimer Market Centre的HIV顧問醫生，以及南非夸祖魯-納塔爾省非洲健康研究所臨床研究的學院負責人。她在社會科學、臨床研究和流行病學之間的跨學科領域擁有專業知識。她在UCL開發了兩個跨學科的碩士課程，分別是人口健康和應用傳染病流行病學。
