Biomedical Imaging in Neurodegeneration
暫譯: 神經退化中的生物醫學影像學

這本新書專注於帕金森病、阿茲海默症及癲癇的生物影像學，呈現最新的技術，用於診斷和治療這些疾病患者，實現個性化醫療。書中包含有關這些技術的「操作知識」章節，涵蓋納米技術及神經退行性疾病早期和晚期生物標記的功能性核子和分子影像。技術在概念、理論和實證方面已經取得了飛躍性的進展。通過神經分子影像（NMI），使用商標為 BRODERICK PROBE(R) 的納米探針生物感測器，對帕金森病（PD）患者的 tau 肽金屬聚合物進行在線影像拍攝，並利用傳統神經網絡（CNN）檢測行走和手部活動模式及帕金森病患者的運動性言語障礙。磁共振影像（MRI）和多巴胺轉運蛋白單光子發射計算機斷層掃描（DAT-SPECT）在退行性帕金森病及相關疾病中，能夠區分帕金森病與本質性顫抖（ET）、帕金森綜合症（PS）及肌張力障礙顫抖（DT），以及包括多系統萎縮（MSA）和進行性核上性麻痺（PSP）在內的非典型帕金森綜合症。影像學方法強調通過 18F-DOPA PET/SPECT 影像進行的分子核影像，並記錄癲癇患者的皮質新皮層 tau 的術中影像，這些影像由 Broderick 納米探針引導的 iMRI 獲得。阿茲海默症患者的亞臨床癲癇樣活動（SAE）被引入作為阿茲海默症患者癲癇的可能表型，而在糖尿病患者的腦幹中使用的刺激範式則與退行性神經病變相關。癲癇疾病的深度，例如癲癇持續狀態（SE），在 MRI 中報告為 T2 增加或液體衰減反轉恢復（FLAIR）。兒童腦結節和局部皮質發育不良在 PET 影像中顯示出高 AMT 吸收，並引入 PET 示蹤劑 alpha[11C]-methyl-L-tryptophan (AMT) 以應對難治性癲癇發作，而質子磁共振光譜（MRS）則深入研究阿茲海默症患者的 N-乙酰天冬氨酸影像。最後，天然大麻化合物（CBD）及其生物化學與 Aβ 肽的關聯，通過 Wnt/β-catenin 及其他有趣的信號通路進行深入討論。本書是尋求有關與阿茲海默症相關的癡呆疾病的示蹤探針和感測探針建議的教科書。讀者將會發現這本書內容全面，希望它能夠擁抱所有人對於人類及類人動物神經退行性問題的活力。

Dr. Patricia A. Broderick, PhD is a Full, Medical Professor with Tenure at the City University of New York Medical School, Dept. of Molecular, Cellular and Biomedical Science, USA where she also holds faculty positions at the CUNY Grad Ctr.: Psychology: Cognitive and Behavioral Neuroscience as well as at CUNY Neuroscience Collaborative Graduate Program: Biology. Patricia served as the Director of Pharmacology at the City University of New York Physician Assistant/MS program at the CUNY Medical School and Director of the Neurobiology of Drugs of Abuse Course as well as Adjunct Professor in Neurology and the Comprehensive Epilepsy Center at NYU Langone Medical Center, USA. As graduate, doctoral, medical, physician assistant and high school mentor, her innovative teaching is deeply appreciated. As principal and founder of Eazysense Nanotechnologies Inc., the Broderick Brain Foundation Inc. and inventor of the BRODERICK PROBE(R) series of nanobiosensors and circuits, Patricia has garnered respect and admiration worldwide. Achieving her PhD in Pharmacology from St. John's University, College of Arts and Sciences, NY, USA, her expertise in the field of atomic absorption photometry and fluorescent spectrometry, her inventive neuroimaging art in the biosensing and bioimaging field at the Albert Einstein College of Medicine and Cornell University, NY, USA, makes sense. Indeed, as postdoctoral fellow, Dr. Broderick was awarded the Rosenbaum Award from Albert Einstein Medical School/Montefiore Hospital and her patents began at the Albert Einstein College of Medicine are now held by CUNY. Patricia has published and patented extensively and has garnered respect for her novel research around the world. The BRODERICK PROBE(R) trademark, named after her father, brings a solid brand as the nanoprobe is poised for marketing her unique cutting-edge nanotechnology in the field of Neuroscience. She is the recipient of multiple grants awards and prestigious honors from organizations such as Inner Circle Executives, Acquisitions International Global/Corporate America, International Association of Professionals, National Association of Distinguished Professionals and Top Industry Experts from Patient Preferred Physicians and Practitioners was celebrated in 2024. A pivotal figure in biosensing technology and the brain, spinal cord and the skin, Broderick served as Session Chair, at the Virtual International Electronic Conference on Brain Sciences, Beijing, October, 2024 and her pending 2025 patent application for replenishing skin as well as her multiple patents are recognized by major diagnostic and pharmaceutical markets, worldwide. Prof. Broderick serves on the editorial boards of several prestigious scientific and medical journals and her work as editor, author and lecturer is renowned. No stranger to the airways, Patricia is a sought-after speaker and her weekly talk show, The Eazysense Show, is at the top of the list at Bold Brave Media (BBM) Productions. Patricia's unwavering dedication to advancing the understanding of neurological, psychological and mental health is reflected in her latest launched textbook, Broderick PA (2025) NEUROIMAGING: Sensing Biochemistry in the Brain, Jenny Stanford Publishing, Pte Ltd., Singapore.The Editor thanks Springe Nature for the opportunity to lead the most talented and influential physicians and scientists in the world via this book, Biomedical Imaging in Neurodegeneration.

Dr. Patricia A. Broderick, PhD 是美國紐約市立大學醫學院分子、細胞與生物醫學科學系的全職終身教授，並在CUNY研究生中心擔任心理學：認知與行為神經科學的教職，以及CUNY神經科學合作研究生計畫：生物學的教職。Patricia曾擔任紐約市立大學醫學院的藥理學主任，並負責藥物濫用神經生物學課程的主任，同時也是紐約大學朗戈醫療中心神經學及綜合癲癇中心的兼任教授。作為研究生、博士生、醫學及醫師助理的導師，她的創新教學深受讚賞。作為Eazysense Nanotechnologies Inc.的創始人及負責人、Broderick Brain Foundation Inc.的創始人，以及BRODERICK PROBE(R)系列納米生物感測器和電路的發明者，Patricia在全球贏得了尊重和讚譽。她在美國紐約聖約翰大學藝術與科學學院獲得藥理學博士學位，並在原子吸收光譜學和螢光光譜學領域擁有專業知識，她在阿爾伯特·愛因斯坦醫學院和康奈爾大學的生物感測和生物成像領域的創新神經影像藝術也相當出色。事實上，作為博士後研究員，Dr. Broderick曾獲得阿爾伯特·愛因斯坦醫學院/蒙特菲奧爾醫院的羅森鮑姆獎，她的專利始於阿爾伯特·愛因斯坦醫學院，現在由CUNY持有。Patricia已廣泛發表和申請專利，並因其創新研究在全球贏得了尊重。BRODERICK PROBE(R)商標以她的父親命名，為這款納米探針帶來了堅實的品牌，並準備在神經科學領域推廣她獨特的尖端納米技術。她獲得了多項獎助金和來自內圈高管、國際收購全球/美國企業、國際專業協會、全國傑出專業人員協會及患者首選醫生和從業者的頂尖行業專家等組織的榮譽，並在2024年受到表彰。作為生物感測技術及大腦、脊髓和皮膚的關鍵人物，Broderick在2024年10月的北京虛擬國際電子大會上擔任會議主席，她的2025年專利申請正在進行中，涉及皮膚再生，並且她的多項專利在全球主要的診斷和製藥市場上受到認可。Broderick教授擔任多本著名科學和醫學期刊的編輯委員會成員，她作為編輯、作者和講師的工作享有盛譽。Patricia在媒體界也不陌生，是一位受歡迎的演講者，她的每週脫口秀《The Eazysense Show》在Bold Brave Media (BBM) Productions中名列前茅。Patricia對於推進神經學、心理學和心理健康理解的堅定奉獻，體現在她最新出版的教科書《Broderick PA (2025) NEUROIMAGING: Sensing Biochemistry in the Brain》，由新加坡的Jenny Stanford Publishing, Pte Ltd.出版。編輯感謝Springer Nature提供機會，通過這本書《生物醫學影像學在神經退行性疾病中的應用》，引領世界上最有才華和影響力的醫生和科學家。