Monoamine Transporters
暫譯: 單胺運輸蛋白

Mortensen, Ole

  • 出版商: Springer
  • 出版日期: 2025-10-07
  • 售價: $8,460
  • 貴賓價: 9.5$8,037
  • 語言: 英文
  • 頁數: 318
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3031963636
  • ISBN-13: 9783031963636
  • 相關分類: 理工類
  • 海外代購書籍(需單獨結帳)

商品描述

The family of monoamine transporters (MATs), composed of the dopamine transporter, serotonin transporter, and norepinephrine transporter, mediates the reuptake of dopamine, serotonin, and norepinephrine from the synapses and extra-synaptic regions, and is thus critical for regulating neurotransmission by controlling the extracellular levels of these neurotransmitters. The monoamine transporters are targets of some of the most successful psychoactive compounds, including amphetamines, cocaine, and antidepressants, among others. Monoamine Transporters will cover significant new information gained over the last decades on these important brain membrane proteins and provide a detailed overview of recent advances in our understanding of the role monoamine transporters play in both normal and disease physiology. This will include in-depth reviews of our current knowledge of their structure, function, and regulation. Translational aspects on diseases where therapeutics targeting the MATs have been successful and helped elucidate the etiology of the respective diseases will also be covered.

商品描述(中文翻譯)

單胺運輸蛋白(MATs)家族由多巴胺運輸蛋白、血清素運輸蛋白和去甲腎上腺素運輸蛋白組成,負責從突觸及突觸外區域重新攝取多巴胺、血清素和去甲腎上腺素,因此對於通過控制這些神經傳遞物質的細胞外濃度來調節神經傳遞至關重要。單胺運輸蛋白是一些最成功的精神活性化合物的靶點,包括安非他命、可卡因和抗抑鬱劑等。《單胺運輸蛋白》將涵蓋過去幾十年來在這些重要的腦膜蛋白方面獲得的重要新資訊,並提供對我們對單胺運輸蛋白在正常和疾病生理中所扮演角色的理解的最新進展的詳細概述。這將包括對我們目前對其結構、功能和調控的知識的深入回顧。還將涵蓋針對MATs的治療在某些疾病中的成功及其如何幫助闡明相關疾病病因的轉化方面。

作者簡介

Ole Valente Mortensen, PhD, is Associate Professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. He is also Director of the Pharmacology & Physiology Graduate Program. He has a long-standing research interest in how monoamine transporters are involved in modulating monoamine signaling and associated behaviors. Dr. Mortensen obtained an MS degree from Tokyo Institiute of Technology in Japan and his PhD degree from Aarhus University in Denmark. He continued his postdoctoral training under the guidance of Dr. Susan Amara at the Vollum Institiute in Portland, Oregon. He was a research assistant professor at the University of Pittsburgh School of Medicine before he joined Drexel University in 2009.

作者簡介(中文翻譯)

Ole Valente Mortensen, PhD 是美國賓夕法尼亞州費城德雷克塞大學醫學院藥理學與生理學系的副教授。他同時也是藥理學與生理學研究生課程的主任。他對單胺運輸蛋白在調節單胺信號及相關行為中的作用有著長期的研究興趣。Mortensen博士在日本東京工業大學獲得碩士學位,並在丹麥的奧胡斯大學獲得博士學位。他在俄勒岡州波特蘭的Vollum研究所接受了蘇珊·阿馬拉博士的指導進行博士後訓練。在2009年加入德雷克塞大學之前,他曾擔任匹茲堡大學醫學院的研究助理教授。