Cellular and Molecular Mechanisms of Chronic Rejection in Organ Transplantation
暫譯: 器官移植中慢性排斥的細胞與分子機制

Kloc, Malgorzata, Ghobrial, Rafik Mark

Cellular and Molecular Mechanisms of Chronic Rejection in Organ Transplantation
  • 出版商: Springer
  • 出版日期: 2026-01-03
  • 售價: $8,920
  • 貴賓價: 9.5 折 $8,474
  • 語言: 英文
  • 頁數: 273
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3032076854
  • ISBN-13: 9783032076854
  • 相關分類: GAN 生成對抗網絡

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Despite improvements in antirejection therapies, solid organ transplantation is hampered by chronic rejection, with around 70% of transplants being rejected within 10 years post-transplantation. Given the growing number of transplant candidates and the shortage of organ donors, finding a cure for chronic rejection is a priority in transplantation. Although chronic rejection studies have increased our knowledge of the subject over the years, the cellular and molecular processes involved in chronic rejection are still not fully understood.

This volume covers the molecular and cellular aspects of the chronic rejection of both solid and composite allografts. It is divided into three parts:

    Part I provides a comprehensive overview and mechanistic understanding of the cellular and molecular pathways underlying chronic rejection, as well as their potential in identifying novel biomarkers and developing targeted anti-chronic rejection strategies. Part II focuses on immune cells, non-immune cells, and extracellular molecules in the context of chronic rejection. Part III concentrates on shared and organ-specific (liver, face, kidney, lung) features as well as the latest therapeutic approaches in chronic rejection.
The book provides a comprehensive overview of the mechanisms and challenges involved, with the aim of inspiring the development of new therapies for chronic rejection.

商品描述(中文翻譯)

儘管抗排斥療法有所改善，實體器官移植仍受到慢性排斥的困擾，約有70%的移植在移植後10年內會被排斥。考慮到移植候選人數量的增加以及器官捐贈者的短缺，尋找慢性排斥的治療方法成為移植領域的優先事項。儘管對慢性排斥的研究在過去幾年中增進了我們對該主題的了解，但涉及慢性排斥的細胞和分子過程仍未完全明瞭。

本書涵蓋了實體和複合同種異體移植的慢性排斥的分子和細胞層面。內容分為三個部分：

第一部分提供了慢性排斥的細胞和分子途徑的全面概述和機制理解，以及它們在識別新型生物標記和開發針對慢性排斥的策略中的潛力。

第二部分專注於慢性排斥中的免疫細胞、非免疫細胞和細胞外分子。

第三部分集中於共享和器官特異性（肝臟、面部、腎臟、肺部）的特徵，以及慢性排斥的最新治療方法。

本書提供了涉及的機制和挑戰的全面概述，旨在激發新療法的開發以應對慢性排斥。

作者簡介

Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital.

R. Mark Ghobrial, M.D., Ph.D., FACS, FRCS (Ed)
J.C. Walter Jr. Presidential Distinguished Chair
Director, J.C. Walter Jr. Transplant Center of Excellence
Director, Transplantation Research
Chief, Division of Transplantation, Department of Surgery
Professor of Surgery, Weill Cornell Medical College
Full Member, Houston Methodist Institute for Academic Medicine
Past-President, International Liver Transplant Society
Email: rmghobrial[at]houstonmethodist.org

Rafik Mark Ghobrial is a Professor of Surgery at Weill Cornell Medical College, Director of the J.C. Walter Jr. Transplant Center, Houston Methodist, Houston, Texas, and he holds the J.C. Walter Jr. Presidential Distinguished Chair. He obtained his MD from Cairo University and PhD from the University of Texas Health Science Center, Houston, Texas. His medical training was completed at Massachusetts General Hospital, University of Texas Health Science Center, and the University of California, Los Angeles (UCLA). He is the recipient of multiple awards and honors and was elected to the Fellowship of The Royal College of Surgeons-Edinburgh and the American Surgical Association. As a researcher, he is the recipient of multiple grants and has held NIH sponsored awards in transplant immunology and clinical sciences. He has authored nearly 300 articles, chapters and has lectured widely, both nationally and internationally, on topics related to liver disease and transplantation. Dr. Ghobrial has served on numerous committees and held multiple advisory and leadership roles and is currently the President of the International Liver Transplant Society.

作者簡介(中文翻譯)

Malgorzata Kloc: 在完成她在加拿大的博士後訓練之前，Kloc 博士曾是波蘭華沙大學動物學系的終身副教授。她還曾擔任加拿大渥太華卡爾頓大學生物學系的研究助理。在完成博士後訓練期間，Kloc 博士獲得了卡爾加里大學的 AHFMR 研究獎和達爾豪斯大學的 MRC 生物技術訓練獎。她於 1987 年加入德克薩斯大學 M.D. 安德森癌症中心，擔任分子遺傳學系的研究科學家，並於 2006 年成為生物化學與分子生物學系的副教授。Kloc 博士於 2008 年加入休斯頓衛理公會研究所。目前，Kloc 博士是休斯頓衛理醫院的韋爾醫學院細胞與分子生物學教授。

R. Mark Ghobrial, M.D., Ph.D., FACS, FRCS (Ed)
J.C. Walter Jr. 總統傑出講座教授
J.C. Walter Jr. 移植卓越中心主任
移植研究主任
外科部移植科主任
韋爾醫學院外科教授
休斯頓衛理醫學院學術醫學全職成員
國際肝臟移植學會前會長
電子郵件: rmghobrial[at]houstonmethodist.org

Rafik Mark Ghobrial 是韋爾醫學院的外科教授，休斯頓衛理醫院 J.C. Walter Jr. 移植中心的主任，並擔任 J.C. Walter Jr. 總統傑出講座教授。他在開羅大學獲得醫學學位，並在德克薩斯大學健康科學中心獲得博士學位。他的醫學訓練在麻薩諸塞州總醫院、德克薩斯大學健康科學中心和加州大學洛杉磯分校（UCLA）完成。他獲得了多項獎項和榮譽，並被選為愛丁堡皇家外科醫師學會和美國外科學會的會員。作為研究人員，他獲得了多項資助，並在移植免疫學和臨床科學方面持有 NIH 贊助的獎項。他已發表近 300 篇文章和章節，並在國內外廣泛講授與肝病和移植相關的主題。Ghobrial 博士曾在多個委員會任職，擔任多個諮詢和領導角色，目前是國際肝臟移植學會的會長。

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