Physiological Mapping of the Cerebral Cortex in Neuropathology: Mitochondrial Function, Cbf, Ionic Homeostasis and Electrical Activities
暫譯: 神經病理學中大腦皮層的生理映射：線粒體功能、腦血流、離子穩態與電活動
Mayevsky, Avraham, Livnat, Amir, Etziony, Revital
- 出版商: Springer
- 出版日期: 2026-05-21
- 售價: $7,400
- 貴賓價: 9.5 折 $7,030
- 語言: 英文
- 頁數: 572
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3032130182
- ISBN-13: 9783032130181
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相關分類:
物理學 Physics
海外代購書籍(需單獨結帳)
相關主題
商品描述
This book covers a new concept and unique approach named "Physiological Mapping" of the cerebral cortex in the rat's brain. The unique parameter that is used in the authors' studies is the monitoring, in vivo and in real time, of the mitochondrial NADH redox state. In addition, the monitoring of cerebral blood flow, tissue oxygen level, extracellular potassium ion and DC potential as well as ECoG is reported.
The main pathological event that was studied was cerebral ischemia that mimic the stroke developed in patients. Different models of ischemia were investigated by using the developed concept of "Physiological Mapping". A unique chapter in the book describes and discuss an event named "Metabolic Oscillations" that developed mainly in the ischemic brain. Also the role of nitric oxide in various pathophysiological conditions such as ischemia, hypoxia, and hypercapnia are discussed.
In addition to stroke, the book describes in detail the physiological mapping of the cerebral cortex in the brain exposed to epilepsy. The interaction between the epilepsy developed in the brain and partial ischemia, nitric oxide, hyperoxia and anesthesia is presented in detail.
The last chapter of the book describes the effects of an animal's age on the responses to ischemia. Also the effects of traumatic brain injury in the rat is discussed.
This is an ideal book for neurologists as well as clinicians in the field of neurosurgery and anesthesiology.
商品描述(中文翻譯)
這本書涵蓋了一個名為「生理映射」（Physiological Mapping）的新概念和獨特方法，針對老鼠大腦皮層進行研究。作者研究中使用的獨特參數是對線粒體 NADH 氧化還原狀態的即時、體內監測。此外，還報告了腦血流、組織氧氣水平、細胞外鉀離子和直流電位以及腦皮層電圖（ECoG）的監測。
主要研究的病理事件是模擬患者中風的腦缺血。通過使用「生理映射」的概念，研究了不同的缺血模型。本書中有一個獨特的章節描述並討論了一個名為「代謝振盪」（Metabolic Oscillations）的事件，該事件主要發生在缺血的大腦中。此外，還討論了氮氧化物在缺血、缺氧和高碳酸血症等各種病理生理條件下的作用。
除了中風，本書詳細描述了暴露於癲癇的腦部生理映射。書中詳細介紹了大腦中發展的癲癇與部分缺血、氮氧化物、高氧和麻醉之間的相互作用。
本書的最後一章描述了動物年齡對缺血反應的影響。同時也討論了老鼠的創傷性腦損傷的影響。
這是一本理想的書籍，適合神經科醫生以及神經外科和麻醉學領域的臨床醫生。
作者簡介
Prof. Avraham Mayevsky is a Professor Emeritus in The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel.
Prof. Avraham Mayevsky's field of research since he started his Post-Doc training with Prof. Britton Chance in 1972, was Energy metabolism, including mitochondrial function in vivo, of the brain mainly and other tissues In Vivo, exposed to various pathophysiological conditions. During the 50 years of activity he was able to accomplish a large number of goals that have a very significant impact on the understanding of pathophysiological processes in the brain and other organs evaluated under In Vivo conditions. His vision was to develop experimental approaches and tools that will enable him to study various physiological processes in experimental animals and at the same time, will be ready for clinical applications.
作者簡介(中文翻譯)
阿夫拉罕·馬耶夫斯基教授（Prof. Avraham Mayevsky）是以色列拉馬特甘巴伊蘭大學（Bar-Ilan University）米娜與埃弗拉德·古德曼生命科學院（The Mina & Everard Goodman Faculty of Life Sciences）及萊斯利與蘇珊·貢達多學科腦研究中心（Leslie and Susan Gonda Multidisciplinary Brain Research Center）的名譽教授。
自1972年與布里頓·錢斯教授（Prof. Britton Chance）開始他的博士後訓練以來，馬耶夫斯基教授的研究領域一直是能量代謝，主要研究大腦的線粒體功能（mitochondrial function）及其他組織在各種病理生理條件下的體內（In Vivo）表現。在50年的研究活動中，他成功達成了許多目標，這些目標對於理解大腦及其他器官在體內條件下的病理生理過程具有非常重要的影響。他的願景是開發實驗方法和工具，使他能夠研究實驗動物中的各種生理過程，同時也能為臨床應用做好準備。
