Human Papillomavirus Epidemiology, Immunology and Cervical Cancer Screening
暫譯: 人類乳突病毒流行病學、免疫學與子宮頸癌篩檢

Villa, Luisa Lina, Sichero, Laura

Human Papillomavirus Epidemiology, Immunology and Cervical Cancer Screening
  • 出版商: Springer
  • 出版日期: 2026-02-16
  • 售價: $7,180
  • 貴賓價: 9.8 折 $7,036
  • 語言: 英文
  • 頁數: 127
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 303217774X
  • ISBN-13: 9783032177742

    • 海外代購書籍(需單獨結帳)

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商品描述

This volume explores the latest advances in Human Papillomavirus (HPV) research, with a focus on epidemiology and screening strategies. It sheds light on the diverse nature of HPV, a heterogeneous group of viruses, and examines its global distribution and impact. Readers will gain insights into diagnostic methods such as DNA methylation screening, which monitors cancer progression in high-risk HPV patients, as well as tests designed to target different HPV genotypes. Moreover, the authors introduce natural immune responses to HPV infections, the role of co-factors in cervical carcinogenesis, and the tumor microbiome.

The book provides a critical analysis of these topics, highlighting gaps in current knowledge and suggesting future research directions. The epidemiological burden of HPV-induced tumors beyond the uterine cervix are also addressed, emphasizing the significant impact on both women and men.

This volume is a must-read for researchers, clinicians, and public health professionals interested in the latest developments in HPV research and its implications for cancer prevention and treatment.

商品描述(中文翻譯)

本卷探討人類乳突病毒（HPV）研究的最新進展，重點關注流行病學和篩檢策略。它揭示了HPV的多樣性，這是一組異質性的病毒，並檢視其全球分佈及影響。讀者將深入了解診斷方法，例如DNA甲基化篩檢，該方法用於監測高風險HPV患者的癌症進展，以及針對不同HPV基因型的測試。此外，作者介紹了對HPV感染的自然免疫反應、協同因子在子宮頸癌發生中的角色，以及腫瘤微生物組。

本書對這些主題進行了批判性分析，突顯了當前知識的空白並建議未來的研究方向。還探討了HPV引起的腫瘤在子宮頸以外的流行病學負擔，強調對女性和男性的重大影響。

本卷是研究人員、臨床醫生和公共衛生專業人員必讀的資料，對於關心HPV研究最新發展及其對癌症預防和治療的影響者尤為重要。

作者簡介

Luisa L. Villa is an Associate Professor in the Department of Radiology and Oncology at the Faculdade de Medicina, Universidade de São Paulo, and Head of Innovation in Cancer Research at the Center for Translational Research in Oncology of the Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil.

For more than 40 years, Dr. Villa has focused on studies of HPV carcinogenesis and vaccine development to prevent HPV infections. Her laboratory pioneered the first high-throughput methods for HPV genotyping and implemented these techniques in the landmark Ludwig-McGill HPV Natural History Cohort, which she co-led for over 15 years. This large international prospective study of HPV infection among women produced numerous influential publications and served as the foundation for additional NIH-funded research, including the HIM study--one of the largest multicenter natural history studies of HPV infection in men. Both studies were conducted at the São Paulo Branch of the Ludwig Institute for Cancer Research under her coordination.

In addition to molecular epidemiological research, Dr. Villa has been a global leader in clinical trials of HPV prophylactic vaccines to prevent cervical cancer. More recently, she serves as multiple Principal Investigator of the ROCCHHA study within ULAC54 net, an international research partnership investigating HPV-related cancers in patients with HIV as part of the National Cancer Institute's U.S.-Latin American-Caribbean Clinical Trials Network.

Dr. Villa has authored more than 400 peer-reviewed articles, which have collectively received approximately 19,000 citations. She has mentored 13 Master's students, 22 Ph.D. candidates, and 8 postdoctoral fellows.

Laura Sichero is a Medical Research Coordinator at the Instituto do Câncer do Estado de São Paulo, and a Collaborator Professor at the Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Laura Sichero has a broad background in Molecular Virology, with specific training and expertise in molecular biology, molecular epidemiology and biochemistry. As PI or co-Investigator on several FAPESP and CNPq-funded grants, I laid the groundwork to the understanding of the impact of mucosal and cutaneous HPV genetic variability upon associated diseases development. I have further made significant contributions in understanding functionally the influence of HPV genetic variability in biological and biochemical properties of infected cells. More recently she is also involved in studies focusing on HPV transcription, and the potential of several cellular transcription factors as biomarkers and drug target in HPV-associated malignancies. Dr. Sichero has authored more than 70 peer-reviewed articles, which have collectively received approximately 2,500 citations. She has mentored 7 Master's students, 10 Ph.D. candidates, and 2 postdoctoral fellows.

作者簡介(中文翻譯)

Luisa L. Villa 是巴西聖保羅大學醫學院放射學與腫瘤學系的副教授，以及聖保羅癌症研究所（Instituto do Câncer do Estado de São Paulo, ICESP）轉譯腫瘤研究中心的癌症研究創新負責人。

超過40年來，Villa博士專注於人類乳突病毒（HPV）致癌機制的研究及疫苗開發，以預防HPV感染。她的實驗室首創了HPV基因分型的高通量方法，並在具有里程碑意義的Ludwig-McGill HPV自然歷史隊列中實施這些技術，該隊列她共同領導了超過15年。這項針對女性HPV感染的大型國際前瞻性研究產生了許多有影響力的出版物，並為後續的國立衛生研究院（NIH）資助研究奠定了基礎，包括HIM研究——這是針對男性HPV感染的最大多中心自然歷史研究之一。這兩項研究均在Ludwig癌症研究所聖保羅分院進行，由她協調。

除了分子流行病學研究外，Villa博士在HPV預防性疫苗的臨床試驗中也是全球領導者，以預防子宮頸癌。最近，她擔任ULAC54網絡中ROCCHHA研究的多位首席研究員，這是一個國際研究夥伴關係，調查HIV患者中與HPV相關的癌症，作為美國國立癌症研究所的美國-拉丁美洲-加勒比臨床試驗網絡的一部分。

Villa博士已發表超過400篇經過同行評審的文章，這些文章總共獲得約19,000次引用。她指導了13名碩士生、22名博士候選人和8名博士後研究員。

Laura Sichero 是聖保羅癌症研究所的醫學研究協調員，並且是巴西聖保羅大學醫學院的合作教授。Sichero擁有廣泛的分子病毒學背景，並在分子生物學、分子流行病學和生物化學方面具有專門的訓練和專業知識。作為多個FAPESP和CNPq資助計劃的首席研究員或共同研究員，她為理解黏膜和皮膚HPV基因變異對相關疾病發展的影響奠定了基礎。她在理解HPV基因變異對感染細胞的生物學和生化特性的功能性影響方面也做出了重要貢獻。最近，她還參與了專注於HPV轉錄的研究，以及幾種細胞轉錄因子作為HPV相關惡性腫瘤的生物標記和藥物靶點的潛力研究。Sichero博士已發表超過70篇經過同行評審的文章，這些文章總共獲得約2,500次引用。她指導了7名碩士生、10名博士候選人和2名博士後研究員。

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