Drugs and a Methodological Compendium: From Bench to Bedside
暫譯: 藥物與方法論彙編:從實驗室到臨床
Rajput, Vikrant Singh, Runthala, Ashish
相關主題
商品描述
商品描述(中文翻譯)
本書提供了從實驗室到臨床的系統性藥物發現與開發的深入見解。這本書涵蓋了藥物分子的發現與開發的幾乎每一個步驟。各章節專注於計算方法、藥理優化方法、現代高通量篩選技術及體外程序、結構生物學家在藥物發現與開發中的角色、藥物設計的藥物化學方法、配方與藥物傳遞、候選分子的體內評估、臨床試驗程序等內容。本書還涵蓋了特定的案例研究、監管批准程序以及工業觀點,並與上述概念框架相結合。同時,本書整合了醫學、生物學、藥學、藥理學和計算科學的相關領域,建議作為分子生物學家、生物化學家、藥理學家、藥物化學家、毒理學家、藥物發現與開發研究人員以及所有對這些學科感興趣的學生的理想指導書。
作者簡介
Vikrant Singh Rajput graduated with B. Tech in Biotechnology (2010) from Amity University, Noida, UP, India, a Ph.D in Biological Science from CSIR-Indian Institute of Integrative Medicine, Jammu, J&K, India (2017). He was awarded postdoctoral fellowship from Indian Institute of Technology (IIT) Roorkee and Young Scientist Award/Research grant from Department of Health Research (Govt. of India). He has also held different positions like Adhoc Faculty at National Institute of Technology (NIT) Raipur, Project scientist at Biosafety Support Unit, Regional Centre for Biotechnology, Faridabad and Scientist at Foundation for Neglected Diseases Research, Bengaluru. He currently works as Assistant Professor at Dept. of Biomedical Engineering, Central University of Rajasthan Ajmer.
Areas of interest: TB biology; TB and anti-bacterial drug discovery; Technologies evaluating PK/PD of TB drugs, Combatting drug resistance; Novel drug targets; Computational drug discovery and immunoinformatics.
Ashish Runthala graduated with M.Sc. in Biological Science (2005) from BITS Pilani, Rajasthan, India. Meanwhile qualifying the National Eligibility test (NET), he pursued the M.E. in Biotechnology (2008) here and completed Ph.D in Computational Biology in 2016. He was awarded the Ucchayatar Avishkar Yojana (UAY) in 2017 from Indian Institute of Science. Starting his academic responsibilities at BITS Pilani from 2005, he has held several positions viz. Teaching Assistant, Assistant Lecturer, Lecturer and Visiting Faculty. He has also worked at Presidency University Bangalore as an Assistant Professor. He is currently working as an Associate Professor at KL University, Vijayawada, and is doing research on developing the functionally improved enzymes of the DXP pathway for enhancing the overall yield of the pathway.
Areas of interest: Computational algorithms; Bioinformatics; Protein structure prediction; Enzyme design; Decoding active site; Designing thermostable enzyme.
作者簡介(中文翻譯)
Vikrant Singh Rajput 於2010年從印度烏塔爾邦諾伊達的阿米提大學(Amity University)獲得生物技術(B. Tech)學位,並於2017年從印度喬克的CSIR-印度綜合醫學研究所(CSIR-Indian Institute of Integrative Medicine)獲得生物科學博士學位。他曾獲得印度理工學院(IIT)魯爾基的博士後研究獎學金,以及印度政府健康研究部的青年科學家獎/研究資助。他還曾擔任過多個職位,包括國立技術學院(NIT)賴普爾的臨時教員、生物安全支持單位的項目科學家、以及班加羅爾的被忽視疾病研究基金會的科學家。他目前在拉賈斯坦中央大學(Central University of Rajasthan)生物醫學工程系擔任助理教授。
研究興趣:結核病生物學;結核病及抗菌藥物發現;評估結核病藥物的藥物動力學/藥效學技術;對抗藥物抗性;新型藥物靶點;計算藥物發現及免疫信息學。
Ashish Runthala 於2005年從印度拉賈斯坦的比特斯比拉尼(BITS Pilani)獲得生物科學碩士學位(M.Sc.),並在通過國家資格考試(NET)後,於2008年獲得生物技術碩士學位(M.E.),並於2016年完成計算生物學博士學位(Ph.D.)。他於2017年獲得印度科學院的Ucchayatar Avishkar Yojana(UAY)獎項。自2005年起,他在比特斯比拉尼開始了學術工作,擔任過多個職位,包括教學助理、助理講師、講師及訪問教員。他還曾在班加羅爾的總統大學擔任助理教授。目前,他在KL大學(KL University)維賈亞瓦達擔任副教授,並進行有關開發功能改進的DXP途徑酶的研究,以提高該途徑的整體產量。
研究興趣:計算算法;生物信息學;蛋白質結構預測;酶設計;活性位點解碼;設計耐熱酶。