商品描述
This book provides a detailed understanding of the complex associations among nutrition, cellular homeostasis, and autophagy through the incorporation of recent scientific advancements as well as practical data focusing on strategies to improve brain health and prolong lifespan. The chapters address in depth the emerging field of nutraceuticals, discussing natural substances that can be incorporated into the diet and have beneficial effects on brain health and promote longevity. The book begins with a comprehensive description of various biological pathways and mechanisms associated with aging and brain health. This highlights the importance of autophagy in maintaining cellular homeostasis and clearing the accumulation of toxic aggregates from cells. The book then goes on to describe how this process of autophagy can be regulated through the use of nutraceuticals and the adoption of a healthy lifestyle, which can potentially contribute to the alleviation of various neurodegenerative disorders and cognitive impairment. The book presents a detailed review of the multiple nutraceuticals currently available, along with their effects on brain aging. These nutraceuticals include polyphenols, omega-3 fatty acids, caloric restriction mimetics, and other phytochemicals. This book thus establishes a link between the incorporation of novel and emerging therapeutic techniques in the field of neuroscience and their applications in everyday life. Researchers, neuroscientists, nutritionists, and healthcare professionals with a focus on brain health, aging, and neurodegenerative diseases will benefit from the book's in-depth scientific insights, research-backed analysis, and exploration of emerging therapeutic techniques for brain health and longevity.
商品描述(中文翻譯)
本書提供了對營養、細胞穩態與自噬之間複雜關聯的詳細理解，結合了最新的科學進展以及專注於改善大腦健康和延長壽命的實用數據。各章節深入探討了營養補充品（nutraceuticals）這一新興領域，討論了可以納入飲食中的天然物質，這些物質對大腦健康有益並促進長壽。
本書首先全面描述了與衰老和大腦健康相關的各種生物途徑和機制，強調自噬在維持細胞穩態和清除細胞內有毒聚集物方面的重要性。接著，本書描述了如何通過使用營養補充品和採取健康的生活方式來調節自噬過程，這可能有助於緩解各種神經退行性疾病和認知障礙。
本書詳細回顧了目前可用的多種營養補充品及其對大腦衰老的影響。這些營養補充品包括多酚、Omega-3脂肪酸、熱量限制模擬劑以及其他植物化學物質。
因此，本書建立了神經科學領域中新興治療技術的納入與其在日常生活中的應用之間的聯繫。專注於大腦健康、衰老和神經退行性疾病的研究人員、神經科學家、營養學家和醫療專業人員將從本書深入的科學見解、研究支持的分析以及對大腦健康和長壽的新興治療技術的探索中受益。
作者簡介
Dr. Abhishek Kumar Singh is an Associate Professor at Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Manipal, Karnataka, India. He has more than fifteen years of research experience in the neurobiology of aging. His major research interest is to investigate the interplay between autophagy and pro-survival pathways during the aging of the brain and aging-induced neurodegenerative disorders, particularly Alzheimer's disease. He has been involved in developing caloric restriction mimetics-based strategies to slow down brain aging and improve health span and lifespan. Dr. Singh has utilized a range of model systems, from cell lines to stem cells to rodents, to understand the mechanisms of the aging process in the brain and develop anti-aging interventions. Dr. Singh has published over 60 research articles in reputed international journals. Dr. Singh has been serving as academic editor of PLOS One and editor of Expert Opinion on Drug Metabolism & Toxicology. He also served as a guest editor and referee for more than 20 international journals with a high impact factor. He is a member of various international scientific societies, including the Indian Academy of Neuroscience and the Society of Toxicology India. Dr. Sachchida Nand Rai is a Senior Research Associate (ICMR-RA) at the Centre of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi. He has won several awards, like the Bentham Outstanding Reviewer Award and Dr. D. S. Kothari Postdoctoral Fellowship (2020-2023). His research expertise covers neurodegenerative disease modeling, epigenetics, autophagy, biochemical and molecular techniques, and bioinformatics. He is serving as Academic Editor for BMC Research Notes (Springer Nature) and PLOS ONE and as Associate Editor for 3 Biotech (Springer Nature) and Oxidative Medicine and Cellular Longevity (Wiley). Additional roles include Editorial Board Member for Molecular Neurobiology, Journal of Inflammation Research, Degenerative Neurological and Neuromuscular Disease, and Emerging Editorial Board Member for Brain Science Advances. He is also a Section Editor for the European Journal of Clinical and Experimental Medicine (Biochemistry Section) and a board member for the International Journal of Psychological and Brain Sciences, Discover Applied Sciences, and Discover Plants.
作者簡介(中文翻譯)
阿比謝克·庫馬爾·辛格博士是印度卡納塔克邦馬尼帕爾高等教育學院的馬尼帕爾生物治療研究中心的副教授。他在老化神經生物學方面擁有超過十五年的研究經驗。他的主要研究興趣是探討自噬與促生存途徑在大腦老化及老化引起的神經退行性疾病（特別是阿茲海默症）之間的相互作用。他參與開發基於熱量限制模擬劑的策略，以減緩大腦老化並改善健康壽命和壽命。辛格博士利用從細胞系到幹細胞再到啮齒類動物的一系列模型系統，來理解大腦老化過程的機制並開發抗老化干預措施。辛格博士在知名國際期刊上發表了超過60篇研究文章。他擔任《PLOS One》的學術編輯以及《Expert Opinion on Drug Metabolism & Toxicology》的編輯。他還擔任超過20本高影響因子的國際期刊的客座編輯和審稿人。他是多個國際科學學會的成員，包括印度神經科學學會和印度毒理學會。
薩奇達·南德·賴博士是印度瓦拉納西的班納拉斯印度大學醫學科學研究所實驗醫學與外科中心的高級研究助理（ICMR-RA）。他獲得了多個獎項，如本塔姆傑出審稿人獎和D.S.科塔里博士後獎學金（2020-2023）。他的研究專長涵蓋神經退行性疾病建模、表觀遺傳學、自噬、生化和分子技術以及生物信息學。他擔任《BMC Research Notes》（Springer Nature）和《PLOS ONE》的學術編輯，以及《3 Biotech》（Springer Nature）和《Oxidative Medicine and Cellular Longevity》（Wiley）的副編輯。其他角色包括《Molecular Neurobiology》、《Journal of Inflammation Research》、《Degenerative Neurological and Neuromuscular Disease》的編輯委員會成員，以及《Brain Science Advances》的新興編輯委員會成員。他還是《European Journal of Clinical and Experimental Medicine》（生化部分）的區域編輯，以及《International Journal of Psychological and Brain Sciences》、《Discover Applied Sciences》和《Discover Plants》的委員會成員。
