Neuroinflammation and Autophagy in Neurodegeneration: Mechanistic Insights Into Cellular Biology and Advanced Multimodal Therapeutics
暫譯: 神經炎症與自噬在神經退行性疾病中的角色：細胞生物學與先進多模態療法的機制洞察

Dr. Pukar Khanal, a research fellow at the School of Medicine, Emory University, GA, United States completed his bachelor's degree in Pharmaceutical Science and master's degree in Pharmacology from KLE University, Belagavi, India, and obtained his Ph.D. from KLE Academy of Higher Education and Research, India. He has been involved in research on neurological, cancer, and endocrine disorders, focusing on identifying potential drug-like small molecules using both computational and experimental approaches, including drug repurposing. He is also interested in utilizing Danio rerio as an alternative animal model and has proposed its use for studying olanzapine-induced weight gain. His current research interests include understanding deregulated metabolic processes in neurodegeneration, particularly glucose and lipid homeostasis in the brain. Dr. Khanal has published research in journals of international repute, serves on the editorial boards of journals such as CNS & Neurological Disorders - Drug Targets, Frontiers in Pharmacology, and Pharmacological Research-Reports, and has been honored with Gold Medals twice by the KLE Academy of Higher Education and Research for his academic achievements.

Dr. B. M. Patil, a life member of the Indian Pharmaceutical Association, Indian Pharmacological Society (IPS), and the Association of Pharmacy Teachers of India (APTI), is currently serving as Senior Professor & Director at Pravara Rural College of Pharmacy, Loni, Maharashtra. With over 35 years of experience in academia and research, Dr. Patil has held various key positions, including Professor, Principal, and Dean at KLE College of Pharmacy, Belagavi and Hubballi, India. Dr. Patil has made significant contributions to pharmacological research, particularly in rodent models of insulin resistance, metabolic syndrome, diabetes, obesity, endothelial dysfunction, and Alzheimer's disease. His research also emphasizes network pharmacology and drug development. He has been instrumental in guiding 8 Ph.D. candidates and 92 M. Pharm dissertations. His expertise has led to securing major research grants, including AICTE-funded projects and collaborations with the Himalaya Drug Company. His research projects have been funded by organizations such as AICTE and industry partners, focusing on areas like marker-assisted selection for metabolic and neurodegenerative diseases. Dr. Patil's contributions to the field have been recognized through several prestigious awards, including the Best Teacher Award, the Prof. M. L. Khorana Memorial Award, and a Certificate of Outstanding Contribution in Reviewing from Elsevier. In addition to his research, Dr. Patil has actively served on numerous academic committees, including Ph.D. selection and registration committees at institutions such as Sanjay Ghodawat University and Rajiv Gandhi University of Health Sciences. He has also been a board member for pharmacy education at several universities.

Dr. Rupesh V. Chikhale is an affiliated scientist with the Cambridge Crystallographic Data Centre at the University of Cambridge, UK with postdoctoral training from the School of Pharmacy, Faculty of Life Sciences, University College London, Dr. Chikhale specializes in structural biology and drug discovery. His research utilizes crystallographic and computational methods to investigate molecular interactions critical to therapeutic development, aiming to identify potential drug candidates in areas where structural data is often limited or challenging to acquire. He has contributed extensively to the field through publications in prominent international journals and collaborative projects in drug discovery. Dr. Chikhale brings expertise in advanced structural biology techniques and data analysis, helping to bridge chemistry and biology innovatively.

Dr. Pukar Khanal，現任美國喬治亞州艾默里大學醫學院的研究員，於印度貝拉戈維的KLE大學獲得藥學學士學位及藥理學碩士學位，並在KLE高等教育與研究學院獲得博士學位。他參與神經、癌症及內分泌疾病的研究，專注於利用計算及實驗方法（包括藥物重定位）識別潛在的類藥物小分子。他也對使用斑馬魚（Danio rerio）作為替代動物模型感興趣，並提出其用於研究奧氮平（olanzapine）引起的體重增加。他目前的研究興趣包括理解神經退行性疾病中失調的代謝過程，特別是大腦中的葡萄糖和脂質穩態。Khanal博士在國際知名期刊上發表研究，並擔任《CNS & Neurological Disorders - Drug Targets》、《Frontiers in Pharmacology》和《Pharmacological Research-Reports》等期刊的編輯委員會成員，因其學術成就兩次獲得KLE高等教育與研究學院的金獎。

Dr. B. M. Patil是印度藥學會、印度藥理學會（IPS）及印度藥學教師協會（APTI）的終身會員，目前擔任馬哈拉施特拉邦Loni的Pravara Rural College of Pharmacy的高級教授及主任。擁有超過35年的學術及研究經驗，Patil博士曾在印度貝拉戈維及哈布巴利的KLE藥學院擔任教授、院長及學院主任等多個重要職位。Patil博士在藥理學研究方面做出了重要貢獻，特別是在小鼠模型的胰島素抵抗、代謝症候群、糖尿病、肥胖、內皮功能障礙及阿茲海默症等領域。他的研究也強調網絡藥理學及藥物開發。他在指導8名博士生及92篇碩士論文方面發揮了重要作用。他的專業知識使他獲得了多項重大研究資助，包括AICTE資助的項目及與喜馬拉雅藥業公司的合作。他的研究項目獲得了AICTE及行業夥伴等組織的資助，專注於代謝及神經退行性疾病的標記輔助選擇等領域。Patil博士在該領域的貢獻獲得了多項著名獎項的認可，包括最佳教師獎、M. L. Khorana紀念獎及Elsevier的卓越評審貢獻證書。除了研究外，Patil博士還積極參與多個學術委員會的工作，包括Sanjay Ghodawat大學及Rajiv Gandhi健康科學大學的博士生選拔及註冊委員會。他也曾擔任多所大學的藥學教育委員會成員。

Dr. Rupesh V. Chikhale是英國劍橋大學劍橋結晶數據中心的附屬科學家，擁有倫敦大學學院生命科學學院藥學系的博士後訓練，專注於結構生物學及藥物發現。Chikhale博士的研究利用結晶學及計算方法來調查對治療開發至關重要的分子相互作用，旨在識別在結構數據通常有限或難以獲得的領域中的潛在藥物候選者。他通過在知名國際期刊上發表的文章及藥物發現的合作項目，對該領域做出了廣泛的貢獻。Chikhale博士擁有先進的結構生物學技術及數據分析專業知識，幫助創新性地橋接化學與生物學。