Drug Repurposing: Exploring Newer Therapeutic Potentials
暫譯: 藥物重定位：探索新療法潛力

本書探討了藥物再利用的領域，重點關注過去的趨勢和發展。書中深入研究了生物活性植物分子的再利用及其在各種治療領域的應用，包括神經系統疾病、糖尿病、心血管疾病和自體免疫疾病。此外，本書還針對再利用藥物以應對傳染病和被忽視疾病的迫切需求進行了探討，包括對於在 COVID-19 管理中藥物再利用策略的深入分析。在各章中，讀者將發現案例研究，突顯出再利用藥物的顯著例子、與監管和專利問題相關的挑戰，以及計算建模和人工智慧在加速藥物發現中的角色。本書是一本重要的資源，展示了藥物再利用如何徹底改變現代醫學並促進製藥研究的範式轉變。

本書對於學生、研究人員、學者和藥理學家來說都是一個寶貴的資源。

​Dr. Ravinder Kaundal is working as assistant professor at NIPER Raebareli. He has done his MS (Pharm.) and Ph.D. in pharmacology and toxicology from NIPER-SAS Nagar, India. He received his postdoctoral training at Yale School of Medicine, New Haven, and Icahn School of Medicine at Mount Sinai, New York. Dr. Ravinder has made an outstanding contribution to the field of pharmacological research and has elucidated the involvement of various pathogenic pathways like oxidative stress, PARP overactivation, inflammation, and apoptosis in cerebral ischemic-reperfusion injury and diabetic neuropathy. Gene regulation is another of his interests and he has developed various tools/methods to study the mechanisms of epigenetic memory. His work is published in journals of high repute and is highly cited. He is a reviewer and editorial board member of several international journals. Also, his research interests are neuropharmacology, drug repurposing, molecular biology, ischemic-reperfusion injuries, and gene regulation.

Dr. Rahul Shukla, working as assistant professor at Department of Pharmaceutics, NIPER Raebareli, India, did Ph.D. in pharmaceutical sciences from CSIR CDRI and J.N.U New Delhi, India, M Pharm from IIT BHU, Varanasi, India and B. Pharm from Jamia Hamdard, New Delhi. He has the experience of as research scientist at Dr. Reddy's Laboratories, India, and D.S. Kothari Post-Doctoral Fellow at Panjab University, India. He has more than ten years of research and academic experience. He has more than 120 publications including 40 book chapters to his credit. He has filed 9 Patent and 1 Copyright. He was awarded SERB International Research Experience (SIRE) Fellow for the year, 2022-2023 fellowship at School of Pharmacy and Biomedical Sciences, University of Central Lancashire, United Kingdom; He also received Science and Engineering Research Board (SERB) Research Grant. His current research interests include targeted drug delivery systems, particle engineering, controlled and targeted delivery for neurodegenerative diseases and cancer and works on repurposing, particle engineering and bioavailability enhancements.

Prof. Shubhini A. Saraf is working as director of the National Institute of Pharmaceutical Education and Research (NIPER), Raebareli (U.P.). Prior to joining NIPER, Raebareli, she was working as a professor in the Department of Pharmaceutical Sciences and Director (R&D) at Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow. Prof. Shubhini is an alumnus of the Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar, India. She has more than 27 years of teaching and research experience. Her research interests include nanotechnology & drug targeting as well as technology policy interventions for health care. Her work extensively discusses surface-decorated lipid nanoparticles for cancer therapy. She has 165 research papers published in journals of repute. Prof. Shubhini has authored 07 books and 22 chapters. She has attended many national and international conferences and delivered many invited lectures. Her administrative and research work has been recognized at various national and international forums. Prof. Shubhini is a sincere administrator, academician, and researcher and is known for her inclusive involvement and untiring hard work. Her contributions to the pharmacy profession are enormous and praiseworthy.

拉文德·考恩達爾博士目前擔任 NIPER Raebareli 的助理教授。他在印度 NIPER-SAS Nagar 獲得藥理學和毒理學的碩士（MS (Pharm.)）和博士（Ph.D.）學位。他在耶魯醫學院（Yale School of Medicine, New Haven）和紐約西奈山醫學院（Icahn School of Medicine at Mount Sinai）接受了博士後訓練。拉文德博士在藥理研究領域做出了卓越的貢獻，闡明了氧化壓力、PARP 過度活化、炎症和細胞凋亡等多種致病途徑在腦缺血再灌注損傷和糖尿病神經病變中的作用。他對基因調控也有興趣，並開發了多種工具/方法來研究表觀遺傳記憶的機制。他的研究成果發表在多個高聲望的期刊上，並受到高度引用。他是多個國際期刊的審稿人和編輯委員會成員。此外，他的研究興趣包括神經藥理學、藥物再利用、分子生物學、缺血再灌注損傷和基因調控。

拉胡爾·舒克拉博士目前擔任印度 NIPER Raebareli 藥劑學系的助理教授。他在印度 CSIR CDRI 和新德里 J.N.U 獲得藥學博士（Ph.D.），在印度 IIT BHU 獲得藥學碩士（M Pharm），並在新德里 Jamia Hamdard 獲得藥學學士（B. Pharm）。他曾在印度 Dr. Reddy's Laboratories 擔任研究科學家，並在印度旁遮普大學擔任 D.S. Kothari 博士後研究員。他擁有超過十年的研究和學術經驗，並擁有超過 120 篇出版物，包括 40 篇書章。他已申請 9 項專利和 1 項版權。他於 2022-2023 年度獲得英國中央蘭開夏大學藥學與生物醫學科學學院的 SERB 國際研究經驗（SIRE）獎學金；同時也獲得科學與工程研究委員會（SERB）研究資助。他目前的研究興趣包括靶向藥物傳遞系統、顆粒工程、針對神經退行性疾病和癌症的控制與靶向傳遞，並致力於藥物再利用、顆粒工程和生物利用度提升的研究。

舒比尼·A·薩拉夫教授目前擔任國家藥學教育與研究所（NIPER）Raebareli（烏塔爾邦）的所長。在加入 NIPER Raebareli 之前，她曾在勒克瑙的巴巴薩希布·比姆拉奧·安貝德卡大學（中央大學）藥學系擔任教授及研發主任。舒比尼教授是印度 Sagar 的 Dr. H.S. Gour University 藥學系的校友。她擁有超過 27 年的教學和研究經驗。她的研究興趣包括納米技術與藥物靶向，以及針對健康照護的技術政策干預。她的研究廣泛討論了用於癌症治療的表面修飾脂質納米顆粒。她在多個知名期刊上發表了 165 篇研究論文。舒比尼教授著有 7 本書和 22 篇章節。她參加了許多國內外會議並發表了多場受邀演講。她的行政和研究工作在各種國內外論壇上得到了認可。舒比尼教授是一位真誠的管理者、學者和研究者，以其包容的參與和不懈的努力而聞名。她對藥學專業的貢獻巨大且值得讚揚。