An Innovative Approach to Understanding and Treating Cancer: Targeting PH: From Etiopathogenesis to New Therapeutic Avenues

Koltai, Tomas, Reshkin, Stephan J., Harguindey, Salvador

  • 出版商: Academic Press
  • 出版日期: 2020-01-16
  • 售價: $5,110
  • 貴賓價: 9.5$4,855
  • 語言: 英文
  • 頁數: 574
  • 裝訂: Quality Paper - also called trade paper
  • ISBN: 0128190590
  • ISBN-13: 9780128190593

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An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity.

The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment.


PART 1: Metabolism and pH physiopathology of cancer
1. Introduction
2. Cancer metabolism
3. The pH alterations in cancer: causes and consequences
4. Lactic acid and its transport system
5. The sodium hydrogen exchanger
6. The voltage gated sodium channels
7. Carbonic anhydrases
8. Proton pumps
9. The sodium/bicarbonate co-transporter
10. Aquaporins
11. Invadopodia and the migration/invasion process
12. The Sp1 transcription factor

PART 1: Therapeutics
13. Pharmacological interventions – Part I
14. Pharmacological interventions – Part II
15. Pharmacological interventions – Part III
16. Pharmacological interventions – Part IV
17. Therapeutics: the scheme
18. Therapeutics: ancillary treatments
19. Preventing metastasis
20. Proton inhibitors in pets’ cancer
21. pH-related nanoparticles in cancer treatment
22. Conclusions and future perspectives