Gasotransmitters in Organ Transplantation: A New Era in Transplant Medicine
Dugbartey, George J.
- 出版商: Springer
- 出版日期: 2024-04-06
- 售價: $6,080
- 貴賓價: 9.5 折 $5,776
- 語言: 英文
- 頁數: 303
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 303148066X
- ISBN-13: 9783031480669
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相關分類:
GAN 生成對抗網絡
海外代購書籍(需單獨結帳)
商品描述
This book covers recent pre-clinical and clinical developments in gasotransmitters (nitric oxide, carbon monoxide and hydrogen sulfide) in all transplantable solid organs - kidney, heart, lung, liver, pancreas and intestine. Gasotransmitters are a class of small endogenously produced gaseous signaling molecules that play important roles in cellular homeostasis and impact physiological and pathophysiological situations. Recently, these gasotransmitters have emerged as potent cytoprotective mediators, possessing therapeutic properties that enable them exhibit their intracellular signaling functions. Hence, alterations in their physiological levels have been associated with various pathologies including cold ischemia-reperfusion injury (IRI) in organ transplantation.
In the context of organ transplantation, a novel therapeutic strategy that is being investigated involves administration of these gasotransmitters to the organ donor or recipient before or after transplantation, or supplementation of standard preservation solution with gasotransmitters during organ graft preservation to mitigate transplant-induced IRI. The book is divided into three parts for easier access: Hydrogen Sulfide in Organ Transplantation, Carbon Monoxide in Organ Transplantation, and Nitric Oxide in Organ Transplantation.
The proposed book presents recent advances in organ graft protection mediated by gasotransmitters against warm and cold IRI in preclinical models of organ transplantation and some selected clinical cases, and seeks to lay the foundation for future clinical applications of these gases. The book is topical and timely, and will serve as a good resource for both educational and didactic purposes in transplant patient care and other aspects of clinical medicine.
商品描述(中文翻譯)
本書涵蓋了氣體傳遞物質（一氧化氮、一氧化碳和硫化氫）在所有可移植固體器官（腎臟、心臟、肺、肝臟、胰臟和腸道）中的最新臨床和臨床前發展。氣體傳遞物質是一類小型內源性產生的氣體信號分子，對細胞內平衡起重要作用，並影響生理和病理情況。最近，這些氣體傳遞物質已經成為強效的細胞保護介質，具有治療特性，使它們能夠發揮其細胞內信號功能。因此，其生理水平的改變與包括器官移植中的冷缺血再灌注損傷（IRI）在內的各種病理狀態有關。
在器官移植的背景下，正在研究的一種新的治療策略涉及在移植前或移植後將這些氣體傳遞物質給予器官供體或受體，或在器官移植過程中將標準保存溶液補充氣體傳遞物質以減輕移植引起的IRI。本書分為三個部分，以便更容易查閱：「硫化氫在器官移植中的應用」、「一氧化碳在器官移植中的應用」和「一氧化氮在器官移植中的應用」。
本書提出了氣體傳遞物質在器官移植的暖缺血再灌注損傷和冷缺血再灌注損傷中對器官移植的保護的最新進展，並介紹了一些選定的臨床案例，旨在為這些氣體的未來臨床應用奠定基礎。本書具有時效性和及時性，將成為移植患者護理和臨床醫學其他方面的教育和教學資源。
作者簡介
George Johnson Dugbartey (BSc, MSc, PhD) is a faculty member of University of Ghana, where he teaches Physiology and Pharmacology at undergraduate and graduate levels. He is also a Research Associate in surgery at London Health Sciences Centre, University of Western Ontario, Canada, where his research focuses on hydrogen sulfide in kidney transplantation. In addition, his research areas also include hydrogen sulfide therapy for diabetic and hypertensive nephropathies, and drug-induced acute kidney injury. He has over 10 years of research experience in the hydrogen sulfide field. Dr. Dugbartey is a well-traveled scholar, educator, and a versatile scientist, and has presented his research findings at a lot of scientific conferences globally. He is also the recipient of several conference awards and research awards including the prestigious Canadian Institutes of Health Research Grant Award. He has about 50 publications in internationally reputable peer-reviewed journals, most of which he is the lead author.
Alp Sener (BA, MD, PhD, FRCSC) is the Chief and Chair of Urology and Director of Kidney and Pancreas Transplant Fellowship Program at Schulich School of Medicine and Dentistry, London Health Sciences Centre and St. Joseph's Hospital, London, Canada. He is an accomplished researcher, with over 20 years of research experience in the areas of kidney transplantation and hydrogen sulfide as a novel pharmacological approach for improved renal graft preservation. Dr. Sener is an internationally recognized kidney transplant surgeon, educator and researcher, with about 200 publications comprising research papers, reviews, conference abstracts and book chapters. He has presented his research findings in many national and international conferences. He is also a
recipient of several prestigious local, national and international research contribution awards including the Canadian Society of Transplantation Research Excellence Award, Western University Dean's Award of Excellence, and Vanguard Award from the American Society of Transplant Surgeons.
作者簡介(中文翻譯)
George Johnson Dugbartey（BSc，MSc，PhD）是加納大學的教職員，他在本科和研究生課程中教授生理學和藥理學。他還是加拿大西安大略大學倫敦健康科學中心的外科研究聯合會員，他的研究重點是腎臟移植中的硫化氫。此外，他的研究領域還包括糖尿病和高血壓腎病的硫化氫治療，以及藥物引起的急性腎損傷。他在硫化氫領域擁有超過10年的研究經驗。Dugbartey博士是一位經驗豐富的學者、教育家和多才多藝的科學家，並在全球許多科學會議上發表了他的研究成果。他還獲得了多個會議獎項和研究獎項，包括享有盛譽的加拿大健康研究所研究獎。他在國際知名的同行評審期刊上發表了約50篇論文，其中大部分是他擔任主要作者。
Alp Sener（BA，MD，PhD，FRCSC）是Schulich School of Medicine and Dentistry倫敦健康科學中心和聖約瑟夫醫院的泌尿科主任和主席，以及腎臟和胰臟移植研究員。他是一位有成就的研究者，在腎臟移植和硫化氫作為改善腎臟移植保存的新型藥理學方法方面擁有超過20年的研究經驗。Sener博士是一位國際知名的腎臟移植外科醫生、教育家和研究者，他的研究成果包括約200篇論文，包括研究論文、評論、會議摘要和專書章節。他在許多國家和國際會議上發表了他的研究成果。他還獲得了多個享有盛譽的本地、國家和國際研究貢獻獎，包括加拿大移植學會研究卓越獎、西安大略大學卓越獎和美國移植外科醫師協會的先鋒獎。
