Biomarkers and Therapeutical Targets for Prion Diseases
暫譯: 朊病毒疾病的生物標記與治療靶點
Legname, Giuseppe, Moda, Fabio
- 出版商: Springer
- 出版日期: 2025-09-27
- 售價: $7,890
- 貴賓價: 9.5 折 $7,496
- 語言: 英文
- 頁數: 320
- 裝訂: Hardcover - also called cloth, retail trade, or trade
- ISBN: 3031970543
- ISBN-13: 9783031970542
海外代購書籍(需單獨結帳)
商品描述
This book explores the intricate landscape of prion diseases, exploring the various methodologies for detecting human and animal prions, emphasizing both current techniques and those under development, as well as emerging techniques and methodologies for biomarker detection in prion diseases, paving the way for improved diagnostic and therapeutic approaches.
The rational development of theranostic small molecules for prion diseases is also included, shedding light on potential treatment. It examines the utility of prion disease diagnostic markers in pre-symptomatic disease stages, offering insights into early detection strategies.
Pharmacological approaches in prion diseases are explored, along with the potential of Lab-on-Chip platforms for monitoring prion and "prion-like" amyloid assembly and behavior. The role of reactive microglia and astrocytes as therapeutic targets is investigated, highlighting novel avenues for intervention.
Furthermore, the book addresses biological fluid biomarkers in human prion diseases, paying special attention to biosafety considerations. Human genetic evidence is analyzed to identify new targets in prion diseases, discussing both opportunities and challenges.
The utilization of RT-QuIC analysis of peripheral tissues and PMCA applications in prion disease diagnosis is examined, along with the extension of seed amplification assays for the clinical diagnosis of neurodegenerative disorders beyond prion pathologies. Overall, the book provides a comprehensive overview of biomarkers and therapeutic targets in prion diseases, encapsulating both current knowledge and emerging trends in the field.
Chapter [Human Genetic Evidence for New Targets in Prion Diseases -Opportunities and Challenges] is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
商品描述(中文翻譯)
這本書探討了朊病毒疾病的複雜領域，研究了檢測人類和動物朊病毒的各種方法，強調了當前技術和正在開發的技術，以及在朊病毒疾病中檢測生物標記的新興技術和方法，為改善診斷和治療方法鋪平了道路。
書中還包括了針對朊病毒疾病的治療診斷小分子的合理開發，闡明了潛在的治療方案。它檢視了在無症狀疾病階段中，朊病毒疾病診斷標記的實用性，提供了早期檢測策略的見解。
書中探討了朊病毒疾病中的藥理學方法，以及 Lab-on-Chip 平台在監測朊病毒和「類朊病毒」澱粉樣蛋白組裝及行為方面的潛力。還調查了反應性小膠質細胞和星形膠質細胞作為治療靶點的角色，突顯了干預的新途徑。
此外，該書還討論了人類朊病毒疾病中的生物液體生物標記，特別關注生物安全考量。分析了人類遺傳證據以識別朊病毒疾病中的新靶點，討論了機會與挑戰。
書中檢視了外周組織的 RT-QuIC 分析和 PMCA 在朊病毒疾病診斷中的應用，以及擴展種子擴增測試以臨床診斷神經退行性疾病的可能性，超越朊病毒病理學。總體而言，這本書提供了朊病毒疾病中生物標記和治療靶點的全面概述，概括了當前知識和該領域的新興趨勢。
章節 [人類遺傳證據為朊病毒疾病中的新靶點 - 機會與挑戰] 可在 link.springer.com 上以創用 CC 署名 4.0 國際許可證開放訪問。
作者簡介
Giuseppe Legname earned his Doctor of Philosophy degree at the University of Warwick, UK. After a long spell in industry in the field of immunotherapy, he moved to the National Institute for Medical Research (NIMR), Medical Research Council in London, UK as a Research Associate. In 1999 he became Assistant Adjunct Professor, and later Associate Adjunct Professor, at the Institute for Neurodegenerative Diseases (IND), University of California at San Francisco, USA, under the direction of 1997 Nobel Laureate Professor Stanley B. Prusiner.
In 2006 he joined the faculty of the Scuola Internazionale Superiore di Studi Avanzati (SISSA) in Trieste, Italy, at the Department of Neuroscience. Currently he is Professor of Biochemistry in the same Department and Coordinator of the PhD Program in Molecular Biology.
The main focuses of his research program are the physiological function of the prion protein in mammals and the mechanisms of prion replication as well as the structural characterization of molecular determinants for prion infectivity.
Fabio Moda earned his Doctor of Philosophy degree in Translational and Molecular Medicine at the University of Milano-Bicocca, Italy. In 2022 he completed his specialization in Clinical Pathology and Clinical Biochemistry at the University of Pavia, Italy. Since 2006, he has been working at the Fondazione IRCCS Istituto Neurologico Carlo Besta in Milan. He is currently an Assistant Professor of Clinical Biochemistry and Clinical Molecular Biology in the Department of Medical Biotechnology and Translational Medicine at the University of Milan and also carries out research and clinical activities as a Biologist Manager at the Carlo Besta Neurological Institute. At the Besta Institute, he is in charge of the biosafety level 3 laboratory (BSL3), where he performs diagnostic tests on cerebrospinal fluids and biochemical analysis of brain tissues collected from patients with prion diseases and other dementias. His research primarily focuses on identifying novel disease biomarkers present in peripheral tissues, including the olfactory mucosa, urine, saliva, tears, and blood of patients with neurodegenerative disorders.作者簡介(中文翻譯)
朱塞佩·萊尼梅於英國華威大學獲得哲學博士學位。在免疫療法領域的工業界工作多年後，他轉至英國倫敦的國家醫學研究所（NIMR），擔任研究助理。1999年，他成為美國舊金山加州大學神經退行性疾病研究所（IND）的助理兼任教授，後來晉升為副教授，並在1997年諾貝爾獎得主斯坦利·B·普魯西納教授的指導下工作。
2006年，他加入意大利的國際高等研究學院（SISSA）神經科學系的教職。目前，他是該系的生物化學教授及分子生物學博士課程的協調員。
他的研究計畫主要集中在哺乳動物中朊病毒蛋白的生理功能、朊病毒複製的機制，以及對朊病毒感染性分子決定因素的結構特徵進行研究。
法比奧·莫達於意大利米蘭-比科卡大學獲得轉化與分子醫學的哲學博士學位。2022年，他在意大利帕維亞大學完成臨床病理學和臨床生物化學的專業訓練。自2006年以來，他一直在米蘭的卡洛·貝斯塔神經病學研究所（Fondazione IRCCS Istituto Neurologico Carlo Besta）工作。目前，他是米蘭大學醫學生物技術與轉化醫學系的臨床生物化學和臨床分子生物學助理教授，同時作為生物學經理在卡洛·貝斯塔神經學研究所進行研究和臨床活動。在貝斯塔研究所，他負責生物安全三級實驗室（BSL3），在該實驗室中，他對來自朊病毒疾病和其他癡呆症患者的腦脊髓液進行診斷測試和生化分析。他的研究主要集中在識別存在於外周組織中的新型疾病生物標記，包括嗅黏膜、尿液、唾液、淚液和神經退行性疾病患者的血液。
