Transposable Elements, Transcriptomics, and Diseases
暫譯: 可轉置元素、轉錄組學與疾病

Vaschetto, Luis M.

Transposable Elements, Transcriptomics, and Diseases
  • 出版商: Springer
  • 出版日期: 2025-11-11
  • 售價: $8,760
  • 貴賓價: 9.5 折 $8,322
  • 語言: 英文
  • 頁數: 435
  • 裝訂: Hardcover - also called cloth, retail trade, or trade
  • ISBN: 3032041244
  • ISBN-13: 9783032041241
  • 相關分類: 生物資訊 Bioinformatics

    • 海外代購書籍(需單獨結帳)

相關主題

商品描述

Transposable elements (TEs) are mobile DNA sequences once referred to as "selfish DNA". While they have contributed significantly to genome evolution, their movement can often disrupt genes and lead to disease. To counteract this, organisms have developed post-transcriptional, transcriptional, and epigenetic mechanisms to control TE activity.

This book explores the complex interplay between mobile genetic elements and human health, providing a comprehensive overview of TE biology, their modes of action, and the strategies employed to suppress their movement, and offering valuable insights into potential therapeutic interventions targeting TE-related diseases. In particular, the book reviews how TEs affect gene expression and contribute to diseases such as cancer, neurodegenerative diseases, and inherited disorders. Other topics include TE polymorphisms, epigenetic control, co-opted functions, non-coding RNAs, and their roles in environmental stress and immune pathways.

Providing a comprehensive reference on the subject, this book is intended for researchers and advanced students in genetics and related disciplines.

商品描述(中文翻譯)

可轉移元素（TEs）是可移動的DNA序列，曾被稱為「自私的DNA」。雖然它們對基因組的演化有著重要的貢獻，但它們的移動往往會干擾基因並導致疾病。為了對抗這種情況，生物體已發展出轉錄後、轉錄和表觀遺傳機制來控制TE的活性。

本書探討了可移動遺傳元素與人類健康之間的複雜相互作用，提供了TE生物學的全面概述，包括它們的作用模式以及抑制其移動所採用的策略，並提供有關針對TE相關疾病的潛在治療干預的寶貴見解。特別是，本書回顧了TE如何影響基因表達並促進癌症、神經退行性疾病和遺傳性疾病等疾病的發展。其他主題包括TE多態性、表觀遺傳控制、共用功能、非編碼RNA及其在環境壓力和免疫途徑中的角色。

本書提供了該主題的全面參考，旨在為遺傳學及相關學科的研究人員和高級學生提供資源。

作者簡介

Luis María Vaschetto obtained his Ph.D. in Biological Sciences from the Universidad Nacional de Córdoba (Argentina). He was a postdoctoral researcher at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and a Research Associate at the South Dakota State University (SDSU). He has first-authored over ten academic articles in top-tier journals such as WIREs RNA, Briefings in Functional Genomics, Journal of Cellular Biochemistry, Molecular Breeding, Current Gene Therapy, RNA Biology, and Current Genetics, and also published several book chapters. Currently, Luis Maria is Series Editor for the Book Series Epigenetics and Human Health (EHH), published by Springer Nature (Switzerland). He has edited and authored eight international books, including two for the EHH series and three for Methods in Molecular Biology (MiMB, Springer Nature, USA). His research mainly focuses on understanding the epigenetic mechanisms involved in plant and animal development, as well as their effects on human health and diseases.

作者簡介(中文翻譯)

Luis María Vaschetto 取得阿根廷科爾多瓦國立大學的生物科學博士學位。他曾在國家科學技術研究委員會（CONICET）擔任博士後研究員，並在南達科他州立大學（SDSU）擔任研究助理。他是多篇頂尖期刊的第一作者，發表的學術文章超過十篇，這些期刊包括 WIREs RNA、Briefings in Functional Genomics、Journal of Cellular Biochemistry、Molecular Breeding、Current Gene Therapy、RNA Biology 和 Current Genetics，並且還出版了幾個書章。目前，Luis María 是由施普林格自然出版（Springer Nature，瑞士）出版的書系列 Epigenetics and Human Health（EHH）的系列編輯。他編輯和撰寫了八本國際書籍，其中包括兩本 EHH 系列的書籍和三本 Methods in Molecular Biology（MiMB，施普林格自然，USA）。他的研究主要集中在理解植物和動物發育中涉及的表觀遺傳機制，以及這些機制對人類健康和疾病的影響。

類似商品