The Golgi Network, Volume I: Golgi Organization and Dynamics
暫譯: 高基網絡，第壹卷：高基體的組織與動態
Nakano, Akihiko, Saraste, Jaakko
相關主題
商品描述
The Golgi apparatus was discovered by Camillo Golgi in 1898. Today, more than 125 years later, the Golgi apparatus is still a key object of active biochemical and cell biological research. The role of this organelle as a glycosylation factory has been well recognized while its function as a central station in protein sorting in membrane trafficking has raised many disputes during the past decades.
Morphologically, the beautiful cisternal stacks are often considered a typical structure of the Golgi, but looking across a variety of eukaryotic species, large variations in Golgi organization become apparent. Despite the long history of Golgi research, there still are many unanswered questions. How are Golgi residents and passing cargo proteins and lipids sorted from each other and find their correct transport routes and final destinations? What are the carriers or mechanisms mediating communication between cisternae - vesicles, tubules, or close membrane contacts? How is the compositional polarity of the organelle between the cis- and trans-sides established and maintained? What are the contributions of lipids in Golgi organization and function? Why do the cisternal Golgi stacks form ribbon structures in vertebrates? What are the precise roles of next-door neighbors of the Golgi - the intermediate compartment (ERGIC/IC) at the cis-face and the trans-Golgi network (TGN) at the trans-face - in its maintenance and function? To address these questions, many new technologies have been developed, leading to exciting discoveries. For example, state-of-the-art microscopic methods, such as high-speed and high-resolution live imaging and correlative light and electron microscopy are regarded as very promising approaches and are therefore undergoing continuous development.
This first volume of two presents the latest knowledge about the Golgi Organization and Dynamics covering different kingdoms from Fungi to Animals, put together by leading experts in the field contributing individual chapters to this book, which represents an exceptional collection of current concepts about the Golgi and its neighboring organelles. As such it is a valuable resource for both researchers and students.
商品描述(中文翻譯)
高基體（Golgi apparatus）是由卡米洛·高基（Camillo Golgi）於1898年發現的。至今，距今已超過125年，高基體仍然是活躍的生物化學和細胞生物學研究的關鍵對象。這個細胞器作為糖基化工廠的角色已被廣泛認可，而其在膜運輸中作為蛋白質分類的中央站的功能在過去幾十年中引發了許多爭議。
在形態學上，美麗的囊泡堆疊常被視為高基體的典型結構，但在不同的真核生物物種中，高基體的組織顯示出顯著的變異。儘管高基體研究歷史悠久，仍然有許多未解答的問題。高基體的居民和經過的貨物蛋白質及脂質是如何彼此分類並找到正確的運輸路徑和最終目的地的？介導囊泡之間通訊的載體或機制是什麼——囊泡、微管還是緊密的膜接觸？這個細胞器在順面（cis-side）和反面（trans-side）之間的組成極性是如何建立和維持的？脂質在高基體的組織和功能中有何貢獻？為什麼在脊椎動物中，囊泡狀的高基體堆疊會形成帶狀結構？高基體的鄰近結構——順面中間室（intermediate compartment, ERGIC/IC）和反面高基網絡（trans-Golgi network, TGN）在其維護和功能中扮演著什麼精確角色？為了解決這些問題，許多新技術已被開發，並導致了令人興奮的發現。例如，最先進的顯微技術，如高速和高解析度的活體成像以及相關的光學和電子顯微鏡技術，被視為非常有前景的方法，因此正在持續發展中。
這本兩卷本的第一卷呈現了關於高基體組織和動態的最新知識，涵蓋了從真菌到動物的不同界，由該領域的領先專家編寫的各章節組成，這本書代表了當前有關高基體及其鄰近細胞器的概念的卓越集成。因此，它對於研究人員和學生來說都是一個寶貴的資源。
作者簡介
Professor Akihiko Nakano is a cell biologist/biochemist with a particular interest in the molecular mechanisms of protein sorting during membrane trafficking and of carrier formation in the trafficking pathways. He explores the roles of membrane trafficking in many aspects of basic biology and life sciences, as well as super-resolution live imaging microscopy and its application. His work on the Golgi cisternal maturation is viewed as a monumental milestone in the field, not least as it helped to settle a big debate about the transport mechanisms in the Golgi apparatus and led to a rewriting of major cell biology textbooks. His group works on several different model systems, using yeast, plant and animal cells.
Professor Jaakko Saraste is a cell biologist/morphologist with a long-term interest in membrane trafficking along the secretory pathway. He is famous for his discovery of the intermediate compartment (IC or ERGIC) operating between the endoplasmic reticulum and the Golgi apparatus and is continuing his investigations on the functional organization of this still enigmatic membrane system. Based on the emerging direct connection between the IC and the endocytic recycling system, he is also interested in the new roles of this compartment in unconventional protein secretion bypassing the Golgi, as well as in cellular egress of coronaviruses.
作者簡介(中文翻譯)
教授中野明彦是一位細胞生物學家/生物化學家，特別關注膜運輸過程中蛋白質排序的分子機制以及運輸途徑中載體的形成。他探討膜運輸在基礎生物學和生命科學的許多方面中的角色，以及超解析活細胞成像顯微鏡及其應用。他在高基體囊泡成熟方面的研究被視為該領域的一個重要里程碑，尤其是因為它幫助解決了有關高基體運輸機制的重大爭論，並導致主要細胞生物學教科書的重寫。他的研究小組使用酵母、植物和動物細胞等多種不同的模型系統進行研究。
教授雅科·薩拉斯特是一位細胞生物學家/形態學家，長期關注沿著分泌途徑的膜運輸。他因發現運作於內質網和高基體之間的中間室（IC或ERGIC）而聞名，並持續研究這個仍然神秘的膜系統的功能組織。基於IC與內吞回收系統之間新出現的直接連接，他也對這個中間室在繞過高基體的非常規蛋白質分泌中的新角色，以及冠狀病毒的細胞排出過程感興趣。
