商品描述
This concise research overview examines sulforaphane, a bioactive isothiocyanate that has become a central focus in nutritional biochemistry, molecular pharmacology, and translational health science. Bringing together evidence from plant biology, enzymology, human metabolism, and clinical research, it traces the compound's pathway from its glucosinolate precursor in Brassicaceae vegetables to its biologically active forms in humans. The book integrates current knowledge on chemical properties, biosynthesis, myrosinase-mediated hydrolysis, and the factors influencing bioavailability, stability, and metabolic variability. Through a critical synthesis of experimental, molecular, and clinical findings, the volume explains how sulforaphane modulates pathways relevant to detoxification, oxidative stress, inflammation, epigenetic regulation, and pharmacokinetics. Coverage of preclinical and human studies outlines therapeutic potential in oncology, neurodegeneration, cardiometabolic disorders, and immune modulation, while also addressing limitations in clinical translation, formulation challenges, and interindividual differences in response. By combining foundational biochemical insights with emerging biomedical applications, the book provides an integrated resource for researchers and professionals in nutrition science, pharmacology, toxicology, functional foods, and translational medicine seeking an authoritative and balanced synthesis of current evidence.
商品描述(中文翻譯)
這本簡明的研究概述探討了硫代葡萄糖素（sulforaphane），這是一種生物活性異硫氰酸酯，已成為營養生物化學、分子藥理學和轉化健康科學的核心焦點。該書整合了來自植物生物學、酶學、人類代謝和臨床研究的證據，追溯這種化合物從其在十字花科蔬菜中的葡萄糖苷前體到其在人體中的生物活性形式的途徑。書中整合了有關化學性質、生物合成、芥子酶介導的水解以及影響生物利用度、穩定性和代謝變異性的因素的當前知識。
通過對實驗、分子和臨床發現的批判性綜合，該書解釋了硫代葡萄糖素如何調節與解毒、氧化壓力、炎症、表觀遺傳調控和藥物動力學相關的途徑。對於臨床前和人類研究的涵蓋，概述了在腫瘤學、神經退行性疾病、心代謝疾病和免疫調節中的治療潛力，同時也討論了臨床轉化中的限制、配方挑戰以及個體間反應的差異。
通過將基礎生物化學見解與新興生物醫學應用相結合，這本書為營養科學、藥理學、毒理學、功能性食品和轉化醫學領域的研究人員和專業人士提供了一個綜合資源，尋求當前證據的權威和平衡綜合。
作者簡介
PharmD, MSc Eng. Kalina Sikorska-Zimny is a food scientist with over 20 years of experience in food chemistry, functional foods, and bioactive plant compounds. Since 2005, her research has focused on health-promoting components of vegetables, particularly Brassicaceae species. She has conducted analytical and experimental studies on glucosinolates and their bioactive derivatives, including sulforaphane and indole-3-carbinol, with special emphasis on their biosynthesis, bioavailability, and health effects. She is the author or co-author of more than 27 scientific publications, including highly cited reviews in Critical Reviews in Food Science and Nutrition (2020) and Nutrients (2021) addressing glucosinolate metabolism and interaction with the human gut microbiota. Her work has been presented at numerous international events, including conferences, invited lectures and academic talks delivered abroad. She serves as a peer reviewer for several leading international journals in the fields of food science, nutrition, and pharmacology. Dr. Sikorska-Zimny has over 15 years of academic teaching experience and is one of two authors of a biochemistry course manual for medical and health-science students.
作者簡介(中文翻譯)
PharmD, MSc Eng. Kalina Sikorska-Zimny 是一位食品科學家，擁有超過 20 年的食品化學、功能性食品和生物活性植物化合物的經驗。自 2005 年以來，她的研究專注於蔬菜的健康促進成分，特別是十字花科（Brassicaceae）植物。她對葡萄糖異硫氰酸酯（glucosinolates）及其生物活性衍生物（包括硫代葡萄糖素（sulforaphane）和吲哚-3-碳醇（indole-3-carbinol））進行了分析和實驗研究，特別強調其生物合成、生物可利用性和健康影響。她是超過 27 篇科學出版物的作者或共同作者，其中包括在《食品科學與營養批判評論》（Critical Reviews in Food Science and Nutrition, 2020）和《營養學》（Nutrients, 2021）中發表的高引用率評論，探討葡萄糖異硫氰酸酯的代謝及其與人類腸道微生物群的相互作用。她的研究成果在多個國際活動中發表，包括會議、受邀演講和國外的學術演講。她擔任多本食品科學、營養學和藥理學領域的國際頂尖期刊的同行評審。Sikorska-Zimny 博士擁有超過 15 年的學術教學經驗，並且是醫學和健康科學學生生物化學課程手冊的兩位作者之一。
