Advances in Antiviral Research

本書介紹了尋找和設計新型抗病毒藥物的先進工具和技術，通過大規模計算虛擬篩選或藥物再利用方法，識別對新興病毒有效的已批准藥物，以及在各種體外和體內模型中對其進行評估。本書的章節還涵蓋了與抗病毒藥物耐藥性的出現相關的挑戰，以及應對這些挑戰的可能方法。它討論了生物信息學工具和軟件以及用於抗病毒藥物發現的計算方法。本書還概述了通過表觀遺傳和表觀轉錄組學靶向重編程設計對多種病毒有效的廣譜抗病毒藥物的方法。此外，它提供了有關藥物申請、臨床試驗及其監管的重要細節。最後，本書全面而具有代表性地描述了抗病毒研究協議和方法的進展，適用於各個職業階段的抗病毒研究人員，包括研究生、博士後和政策制定者。

Dr. Naveen Kumar is a Scientist at the National Institute of High Security Animal Diseases, Bhopal, India. He is an evolutionary biologist specialized in virus evolution and with a background in synthetic biology, molecular, and clinical virology. His primary research interests focus on viral genomics, nanoparticles-based diagnostics, therapeutics, and vaccines for emerging and re-emerging zoonotic viruses, primarily Influenza and SARS-CoV-2 viruses. He also employs selective genetic and evolutionary tools to comprehend the dynamics of virus evolution. He has been conferred with many prestigious honours, including the Young Scientist Award from the Indian Virological Society, the SERB-International Travel Grant for attending ASV-2018 at the University of Maryland in the United States, and the International Federation of Biosafety's Biorisk Management Certification. He had developed a number of diagnostic technologies, including one for which a patent has been granted onsynthetic-biology inspired diagnostics. He holds editorial positions in many international prestigious journals, such as Associate Editor of BMC Microbiology, Guest Associate Editor of Frontiers in Microbiology, Editorial Member of BMC Genomics and PLOS ONE, and Review Editor of Frontiers in Veterinary Science. He has served as a referee for a number of International journals, including Briefings in Bioinformatics (Oxford Academic), Scientific Reports (Nature), and Viruses (MDPI). He has also published more than 50 research articles in the peer-reviewed international journals and authored or co-authored numerous book chapters. He is a member of many national and international scientific societies and organizations importantly, American Society of Virology, Indian Virological Society, and Society of Biosafety, India.

Prof. Yashpal Singh Malik is currently the Dean of the College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India. He is a recipient of the prestigious position "ICAR National Fellow" at the ICAR-Indian Veterinary Research Institute. His areas of expertise are rotaviral diseases, viral disease epidemiology, microbial biodiversity, host-virus interactions, and pathogen-diagnostics. He has pursued advanced studies in molecular virology at the University of Minnesota, USA; University of Ottawa, Ontario, Canada; and Wuhan Institute of Virology, Wuhan, China. He is the recipient of several prestigious national, state and academy awards and honors, including the ICAR-Jawaharlal Nehru Award. He has authored 8 books, 62 book chapters, and over 250 research and review articles. Dr Malik has been associated with societies of international repute, like, the Secretary General of the World Society for Virology (USA) and at national level serving as Secretary General of Indian Virological Society. Being a member in "One Health group in Federation of Asian Veterinary Association" (FAVA) for 2021-2025, he is the Indian flag bearer on the international forum. Dr. Malik is the Editor-in-Chief of the Journal of Immunology Immunopathology and has also edited special issues of the Springer journal Virus Disease, Bentham's The Open Virology Journal, and the Journal of Current Drug Metabolism. He has been awarded a prestigious Fellowship by the Academy of Microbiological Sciences (AMSc), National Academy of Veterinary Sciences and National Academy of Dairy Sciences.

Dr. Shailly Tomar is currently serving as the Professor in the Department of Biosciences and Bioengineering at Indian Institute of Technology Roorkee, India. Dr. Tomar is the reviewer of various prestigious journals like; Journal of Virology, Antiviral research, Scientific reports, The Journal of Vector Borne Diseases, BMC, Biochemistry, BMC Structure biology, Current Chemical Biology, PLOS One, Acta Crystallographica Section D IUCR, and Journal of Biomolecular screening. She has been conferred with various prestigious awards notably, DST young scientist award (2006), Institute Research Fellowship for Outstanding Young Faculty (2018), Visiting Scientist in Karolinska Institute, Sweden Research Council (SRC) Grant (2019), Visiting Scientist, OVDF DST SERB in Purdue University, USA (2019). Her research group focuses on diseases caused by positive-sense ssRNA viruses including Chikungunya, Dengue, Influenza and SARS- CoV-2. Her laboratory is working towards discovery of antiviral therapeutics against infectious (+) ssRNA viruses and developing VLP based vaccines by employing structural biology, cell biology, molecular biology, biochemistry, computational biology, protein-protein interactions, and molecular biophysics techniques. The molecular virology lab of Prof. Tomar specializes in virus propagation, quantification, detection, antiviral assays and discovery of antiviral molecules. She has more than 15 years of teaching experience in Fundamentals of Biotechnology, Advance Virology, Geneticsand Molecular Biology, Biophysical techniques, Separation and Analysis of Biomolecules. Prof. Tomar has published more than 70 research articles in the peer-reviewed international journals and authored or co-authored several books and book chapters. She has organized various conferences and workshops mainly "Indo-US International Conference on Recent Advances in Structural Biology and drug discovery", "Recent Advancements in Biophysical Techniques and Virology", "48^th National Seminar on Crystallography" at IIT Roorkee. She is a member of many international scientific societies and organizations importantly, Member of American Society for Virology (ASV), Member of American Society for Microbiology (ASM), Member of Indian crystallography society (ICA), Life Member of Indian Biophysical Society (IBS), and Life member of Indian Virology Society (IVS), India.

Dr. Sayeh Ezzikouri is a Research Director and Head of viral hepatitis laboratory, Pasteur Instituteof Morocco. He has earlier served as Researcher in the Virology Unit at Pasteur Institute of Morocco (2007-2016), Visiting Professor at Joint Faculty of Veterinary Medicine, Kagoshima University, Japan (2013-2015), and Visiting Scientist at Joint Faculty of Veterinary Medicine, Kagoshima University, Japan (2020). His research interests included but not limited to the public health, virus-host interactions, drug design, and HLA-based peptide vaccine design with specialization in viral hepatitis A, B, C, D, and E, non-primates hepacivirus, HIV, HPV, Zika virus, SARS-CoV-2, and liver cancer. He has served as referee for a number of International journals. He has more than 12 years of teaching experience in virology and molecular biology. He authored/co-authored of more than 100 research articles in the peer-reviewed international journals. Dr Ezzikouri is a member of the the Training and Career Development Committee of the World Society for Virology (USA). He is recipient of many national and international awards. He is a member of many international scientific societies and organizations.

Dr. Naveen Kumar是印度博帕爾國家高安全動物疾病研究所的科學家。他是一位專門研究病毒進化的演化生物學家，具有合成生物學、分子學和臨床病毒學的背景。他的主要研究興趣集中在病毒基因組學、基於納米粒子的診斷、治療和新興和再現性人畜共通傳染病病毒（主要是流感和SARS-CoV-2病毒）的疫苗。他還使用選擇性的遺傳和演化工具來理解病毒進化的動態。他獲得了許多著名的榮譽，包括印度病毒學會的青年科學家獎、印度國際旅行補助金（用於參加美國馬里蘭大學的ASV-2018）和國際生物安全聯合會的生物風險管理認證。他開發了許多診斷技術，其中一項已獲得合成生物學啟發診斷的專利。他在許多國際著名期刊擔任編輯職位，如BMC微生物學的副編輯，Frontiers in Microbiology的客座副編輯，BMC基因組學和PLOS ONE的編輯成員，以及Frontiers in Veterinary Science的審稿編輯。他曾擔任多個國際期刊的審稿人，包括Briefings in Bioinformatics（牛津學術）、Scientific Reports（自然）和Viruses（MDPI）。他還在同行評審的國際期刊上發表了50多篇研究文章，並撰寫或合著了許多專書章節。他是許多國家和國際科學學會和組織的成員，尤其是美國病毒學會、印度病毒學會和印度生物安全學會。

Prof. Yashpal Singh Malik目前是古魯安格德獸醫和動物科學大學動物生物技術學院的院長，位於印度盧迪亞納。他是印度獸醫研究所的“ICAR國家研究員”職位的得主。他的專業領域包括輪狀病毒疾病、病毒疾病流行病學、微生物生物多樣性、宿主-病毒相互作用和病原體診斷。他在美國明尼蘇達大學、加拿大安大略大學渥太華分校和中國武漢病毒研究所進行了分子病毒學的高級研究。他獲得了多個著名的國家、州和學院的獎項和榮譽，包括ICAR-Jawaharlal Nehru獎。他撰寫了8本書、62個書章和250多篇研究和評論文章。Malik博士與國際聲譽卓著的學會有關聯，如世界病毒學學會（美國）的秘書長，以及印度病毒學會的秘書長。作為“亞洲獸醫協會聯合會”的“一個健康小組”的成員（2021-2025年），他是國際論壇上的印度代表。Malik博士是《免疫學免疫病理學雜誌》的主編，並編輯了Springer期刊《病毒疾病》、Bentham的《開放病毒學雜誌》和《當前藥物代謝學雜誌》的特刊。他獲得了微生物科學院（AMSc）、國家獸醫科學院和國家乳品科學院的重要獎學金。

Dr. Shailly Tomar目前在印度魯爾基爾印度理工學院的生物科學與生物工程系擔任教授。Tomar博士是多個著名期刊的審稿人，如《病毒學雜誌》、《抗病毒研究》、《科學報告》、《傳媒傳播疾病學雜誌》、BMC、生物化學、BMC結構生物學、當前化學生物學、PLOS One、Acta Crystallographica Section D IUCR和《生物分子篩選學雜誌》。她獲得了多個著名獎項。